Interesting but flawed
So I made "You Only Live Once", not sure whether you played it? Obviously there's not a great load of similarities except the permanency "feature" (you seem to have been a lot more inspired by "Every Day the Same Dream"). I'm really happy to see more people play with the permanency idea (like me and for example Jesse Venbrux did before me) and your twist on the "genre" (if 3-4 games could be said to make a genre) is a great one that hasn't been done before. That said, I think your game has a few serious flaws.
The first thing I find troublesome is the problem of lack of information. I don't mean in the sense that you don't know exactly where each path will lead, which would obviously ruin the game, but for example choosing the "work" option you don't really get any clues what the hell is going on, whether you're wasting your time or if you're slowly edging closer to finding a cure. It feels wrong you wouldn't share this information with the player, because it creates a distance between him/her and the character, who obviously must have some idea whether he's getting anywhere or not.
The second flaw is the misogyny. I mean maybe it's wrong to point fingers at this game in particular but it bothered me in EDtSD as well. The woman stays at home, while the man works. Do we need to cling to these stereotypes still, in every single game? Just give her a job, damn it, or at least a good explanation for having her stay home all day.
The third, most damning flaw is the main premise of the game. Since I've only played it once (naturally) I can't be sure, but there seems to be only three different paths - work, mistress, or family. But even with such a limited set of choices you don't get the option to spend time with your family until a few days in, and I found the game would more times than not not let me do the things I'd want to. To name just a few things I missed: the option to commit suicide (I felt like jumping from that roof, for example), the option to kill your family, the option to go back to an area you left, etc. For being a game that sets out to be about choice, the amount of choices you get is pretty underwhelming, and as a result the game feels like it was under-developed (or rushed?), and unfortunately falls short of its true potential.
Still, I really liked the game and it was definitely interesting. Keep at it.